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KMID : 0375319940160010081
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Journal of Clinical Pathology and Quality Control
1994 Volume.16 No. 1 p.81 ~ p.88
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Comparison of Semiquantitative tests for Microalbuminuria
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Abstract
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Background :
Microalbuminuria is known as a predictor for later clinical diabetic nephropathy in both insulin-dependent and non-insulin-dependent diabetic mellitus. There are many reports that careful managements of microalbuminuria can reverse elevated
urinary
albumin excretion, and that early detection of microalbuminuria are important for the prevention of diabetic nephropathy. We compared two commercial semiquantitative screening test kits, Micral-test and Microbumintest for microalbuminuria.
methods:
twenty-four hour urine albumin were measured with nephelometer from 38 diabetic patients. Micral-test and Microbumintest were assayed concurrently with spot urine samples collected two times with 24 hour intervals.
Results:
Eleven patients showed urine albumin excretion more than 30 mg per 24 hour. Micral-test showed sensitivities of 90.9% and specficities of 55.6%, when 20 mg/L and more were cut-off values, Microbumintest showed sensitivities of 90.9% and
specficities
of 70.3%, when one positive(40-80 mg/L) and more were cut-off values. If both repeated tests are more than 50 mg/L for Micral-test and two positive(80 mg/L) for Microbumintest. Positive predictive values are increased to 100%, or 87.5%
respectively.
Conclusions:
Confirmatory urine albumin quantitation would be required when 20 mg/L or more with Micral-test and "one positive" or more with Microbumintest for the diagnosis of microalubuminuria. But confirmatory urine albumin quantitation would not be
necessary
with repeatedly 50 mg/L or more with Micral-test and repeatedly "two positive" with Microbumintest.
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KEYWORD
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